Trials / Completed
CompletedNCT05209230
Is Myocardial Stunning Induced by Continuous Renal Replacement Therapy a Reality in Critically Ill Patients?
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 42 (actual)
- Sponsor
- Hospices Civils de Lyon · Academic / Other
- Sex
- All
- Age
- 18 Years – 90 Years
- Healthy volunteers
- Not accepted
Summary
Myocardial stunning during chronic intermittent hemodialysis is a well-described phenomenon. Little case series of patients presenting myocardial stunning during renal replacement therapy for acute kidney injury in critically ill patients are reported, with intermittent hemodialysis and continuous renal replacement therapy. However, the small sample sizes and the absence of a control arm limit their interpretation, mainly whether the myocardial stunning may be related to cardiac loading conditions variations and whether it may impact the hemodynamic. The investigator hypothesize that myocardial stunning induced by renal replacement therapy is frequent, independent from cardiac loading conditions and associated with peripheral hypoperfusion.
Conditions
- Acute Kidney Injury KDIGO 3
- Continuous Renal Replacement Therapy Initiated by the Clinician in Charge Without Emergency
- Myocardial Stunning
Interventions
| Type | Name | Description |
|---|---|---|
| PROCEDURE | Continuous renal replacement therapy | Continuous renal replacement therapy (veno venous hemofiltration) without net ultrafiltration, through a dedicated central venous catheter |
| OTHER | Control group | Continuous renal replacement therapy is differed from 6 hours to allowed 2 control echocardiographic evaluations |
Timeline
- Start date
- 2022-04-15
- Primary completion
- 2025-12-18
- Completion
- 2025-12-18
- First posted
- 2022-01-26
- Last updated
- 2026-01-08
Locations
3 sites across 1 country: France
Source: ClinicalTrials.gov record NCT05209230. Inclusion in this directory is not an endorsement.