NCT05206227

Histamine as a Molecular Transducer of Adaptation to Exercise

• Status: Active Not Recruiting
• Phase: EARLY_Phase 1
• Study type: Interventional
• Enrollment: 80 (estimated)
• Sponsor: University of Oregon · Academic / Other
• Sex: All
• Age: 18 Years – 40 Years
• Healthy volunteers: Accepted

Summary

This study is investigating the role of histamine in generating adaptation to exercise

Detailed description

Exercise promotes and maintains healthy cardiovascular, musculoskeletal, and metabolic function, but the signals and mechanisms which transduce these effects are poorly understood. Histamine plays a role in some of the positive benefits of exercise. The goal of this study is to determine the factors that regulate exercise's effects on endothelial and vascular function, with a focus on histamine released from mast cells in skeletal muscle. Participants will perform exercise or participate in interventions like heating that may replicate some of the effects of exercise. During most experiments, investigators will insert an intravenous catheter in an arm vein and microdialysis probes in the leg, collect dialysate from the microdialysis probe and blood from the vein, record noninvasive measures, and have the participants perform exercise or undergo heating.

Conditions

• Postexercise Hypotension

Interventions

Type	Name	Description
BEHAVIORAL	Aerobic Exercise	Subjects will complete a single bout of aerobic exercise.
DRUG	alpha-FMH	Subjects will undergo either local heating with diathermy or whole body heating with far-infrared sauna.
BEHAVIORAL	Resistance and Aerobic Exercise	Subjects will complete bouts of resistance and aerobic exercise.
DRUG	Antihistamine	Subjects will complete a single bout of aerobic exercise under placebo vs antihistamine conditions.

Timeline

• Start date: 2021-07-28
• Primary completion: 2025-12-31
• Completion: 2027-03-31
• First posted: 2022-01-25
• Last updated: 2026-01-23

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study