NCT05205980

Perturbation Training Reduces Falls in People With Alzheimer's Disease (AD)

Motor Learning of Fall Resistant Skills From Laboratory-induced Falling Among People With Mild Alzheimer's Disease

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (estimated)
• Sponsor: Georgia State University · Academic / Other
• Sex: All
• Age: 65 Years – 90 Years
• Healthy volunteers: Not accepted

Summary

This study will examine the overall capacity of people with Alzheimer's disease learning fall-resistant skills from perturbation training.

Detailed description

Falls can cause injury and death in older adults. Those with Alzheimer's disease are at an even higher fall risk. Our goal is to test if people with mild Alzheimer's disease can learn fall prevention skills from the exposure to large-scale perturbations on a treadmill. Two groups with mild Alzheimer's disease will be enrolled. One group will attend a perturbation training session while the other group receives no training. Groups will then be exposed to perturbations on the ground immediately and three or six months after the training. Over six months after the training, daily-living falls will be tracked for both groups. The falls following the perturbations in the lab and daily-living all-cause falls will be compared between groups to test our specific aims: 1) to test if people with Alzheimer's disease can adapt to large-scale external perturbations and learn fall resistant motor skills; 2) to inspect whether people with Alzheimer's disease can retain motor skills learned in Aim 1; and 3) to determine if people with Alzheimer's disease can generalize fall resistant skills to different contexts (treadmill to overground, inside the lab to outside the lab).

Conditions

• Alzheimer Disease

Interventions

Type	Name	Description
BEHAVIORAL	Perturbation training	Participants will experience repeated perturbations mixed with non-perturbed trials on the treadmill with the protection by a harness.

Timeline

• Start date: 2023-04-28
• Primary completion: 2026-10-30
• Completion: 2026-10-30
• First posted: 2022-01-25
• Last updated: 2026-02-04

Locations

1 site across 1 country: United States