NCT05205031

Intravenous Vs. Intraosseous Vascular Access During Out-of-Hospital

Intravenous Vs. Intraosseous Vascular Access During Out-of-Hospital Cardiac Arrest - a Randomized Clinical Trial

• Status: Active Not Recruiting
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 1,479 (actual)
• Sponsor: Lars Wiuff Andersen · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The "Intravenous vs. Intraosseous Vascular Access During Out-of-Hospital Cardiac Arrest (IVIO)"-trial is an investigator-initiated, randomized, parallel group, patient and outcome assessor-blinded, superiority trial of intravenous vs. intraosseous vascular access during adult out-of-hospital cardiac arrest. The intraosseous group will be further randomized to humeral vs. tibial access. The trial will be conducted in the Central Denmark Region. The primary outcome will be sustained return of spontaneous circulation, and 762 patients will be included. Key secondary outcomes include survival at 30 days and survival at 30 days with a favorable neurological outcome.

Conditions

• Cardiac Arrest

Interventions

Type	Name	Description
DEVICE	Intraosseous access	Needle placed in the bone marrow.
DEVICE	Intravenous	Needle placed in a vein.

Timeline

• Start date: 2022-03-01
• Primary completion: 2024-05-05
• Completion: 2025-05-05
• First posted: 2022-01-24
• Last updated: 2024-09-19

Locations

5 sites across 1 country: Denmark