NCT05200078

Deep Inspiration Breath-hold Radiotherapy for Left-sided Breast Cancer

Deep Inspiration Breath-hold Radiotherapy for Left-sided Breast Cancer in Reducing Early Cardiac Injury: a Phase II Prospective Study

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 166 (estimated)
• Sponsor: Shu lian Wang · Unknown
• Sex: Female
• Age: 18 Years – 70 Years
• Healthy volunteers: —

Summary

Postoperative breast radiotherapy (RT) has been associated with increased risk of heart toxicity. However, there is a lack of knowledge for radiation-induced early cardiovascular injury, especially for hypofractionated RT. This study aims to prospectively detect and predict early clinical or subclinical cardiac events in women undergoing adjuvant RT for breast cancer.

Detailed description

Women with left-sided breast cancer undergo hypofractionated RT at either free-breathing or deep inspiration breath-hold. The incidence and potential clinical, dosimetric and biological indicators of early clinical or subclinical cardiac injury are investigate at 2 years.

Conditions

• Breast Cancer
• Cardiac Event

Interventions

Type	Name	Description
DEVICE	Deep inspiration breath-hold technique	Selective application of deep inspiration breath-hold technique

Timeline

• Start date: 2021-09-01
• Primary completion: 2022-06-30
• Completion: 2023-06-30
• First posted: 2022-01-20
• Last updated: 2022-01-20

Locations

1 site across 1 country: China