NCT05199948

Weight, Energy, Lipids, and the Liver (WELL) Study

Weight, Energy, Lipids, and the Liver (WELL) Study: Dietary Fat Quality and Ectopic Lipids in the Liver

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 74 (estimated)
• Sponsor: Ohio State University · Academic / Other
• Sex: All
• Age: 22 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

The research study is a parallel arm, randomized placebo-controlled clinical trial designed to assess changes in hepatic lipid accumulation, visceral adipose tissue and postprandial lipid, markers of inflammation and energy metabolism in participants who consume 3 study foods per day for 16 week, while maintaining their body weight.

Detailed description

The study objectives include: 1. To determine the impact of dietary soybean oil on ectopic liver fat and visceral adipose in adults with nonalcoholic fatty liver disease (NAFLD) or similar diagnosis 2. To evaluate the effect of soybean oil supplementation on postprandial lipids, markers of inflammation and energy metabolism 3. To measure the strength of the association of change in plasma linoleic acid with changes in ectopic liver fat, visceral adipose, and postprandial lipids, markers of inflammation and energy metabolism 4. To explore emerging mechanistic targets of LA-rich soybean oils that are linked with reduced liver fat and better cardiometabolic health

Conditions

• Nonalcoholic Fatty Liver

Interventions

Type	Name	Description
OTHER	Soybean Oil Foods	Three food product containing 10g of soybean oil each will be consumed each day for a today of 30g of soybean oil consumed each day
OTHER	Palm Oil Foods	Three food product containing 10g of palm oil each will be consumed each day for a today of 30g of palm oil consumed each day

Timeline

• Start date: 2022-05-02
• Primary completion: 2025-09-01
• Completion: 2026-02-01
• First posted: 2022-01-20
• Last updated: 2025-12-09

Locations

1 site across 1 country: United States