NCT05198648

Trigeminal Nerve Cardiac Reflex During Resection of Cerebellopontine Angle Tumors and Postoperative Myocardial Injury

Trigeminal Nerve Cardiac Reflex During Resection of Cerebellopontine Angle Tumors and Postoperative Myocardial Injury: a Prospective Cohort Study

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 476 (actual)
• Sponsor: Beijing Tiantan Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Myocardial injury after noncardiac surgery is significantly related to postoperative 30-day mortality. Trigeminal cardiac reflex is one of the main causes of perioperative cardiac emergency. Therefore, the investigators' aim is to test the hypothesis that trigeminal cardiac reflex associates postoperative myocardial damage in participants undergoing skull base tumor surgery. The investigators will observe the association between trigeminal cardiac reflex and myocardial injury by measuring the concentration of plasma high sensitivity cardiac troponin (hs-cTnT) in participants after skull base tumor surgery.

Conditions

• Myocardial Injury
• Trigeminal Cardiac Reflex

Interventions

Type	Name	Description
OTHER	Trigeminal cardiac reflex	Trigeminal cardiac reflex occurred during the cerebellopontine angle tumor surgery.
OTHER	Non-trigeminal cardiac reflex	No trigeminal cardiac reflex occurred during the cerebellopontine angle tumor surgery.

Timeline

• Start date: 2022-07-01
• Primary completion: 2024-10-01
• Completion: 2024-10-09
• First posted: 2022-01-20
• Last updated: 2025-02-14

Locations

1 site across 1 country: China