NCT05198050

Letrozole in Induction of Abortion of Anembryonic Pregnancy

Letrozole Plus Misoprostol Versus Misoprostol Alone in Induction of Abortion of Anembryonic Pregnancy:

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 96 (actual)
• Sponsor: Cairo University · Academic / Other
• Sex: Female
• Age: 18 Years – 40 Years
• Healthy volunteers: Not accepted

Summary

Some studies suggest the prescription of aromatase inhibitors prior to the use of misoprostol for inducing drug abortion. the aim of the study is to compare the effectiveness of various regimens of letrozole combined with misoprostol versus using misoprostol alone in inducing complete abortion in patients with blighted ovum.

Detailed description

Some studies suggest prescription of aromatase inhibitors prior to the use of misoprostol for inducing drug abortion, increases the efficiency of the treatment regimen and also decreases the need for surgical interventions. Some conducted studies have mentioned reinforcing the impact of misoprostol with letrozole, but reaching the ideal dose still needs more studies, so in this study, the investigators will compare the effectiveness of various regimens of letrozole ( 10 mg/d for 3 days or a single dose of 20 mg) combined with misoprostol versus using misoprostol alone in inducing complete abortion in patients with a blighted ovum.

Conditions

• Anembryonic Pregnancy

Interventions

Type	Name	Description
DRUG	Letrozole tablets	Letrozole is a third-generation non-steroidal aromatase inhibitor
DRUG	Misoprostol Tabets	a synthetic prostaglandin medication
DRUG	Placebo tablets	Placebo tables with a similar appearance to letrozole

Timeline

• Start date: 2022-04-03
• Primary completion: 2022-09-30
• Completion: 2022-09-30
• First posted: 2022-01-20
• Last updated: 2023-09-11

Locations

1 site across 1 country: Egypt