NCT05197543

AAA Rupture Risk Assessment in COVID-19 Pandemic

Biomechanical Rupture Risk Assessment in Management of Patients With Abdominal Aortic Aneurysm in COVID-19 Pandemic

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 102 (actual)
• Sponsor: Masaryk University · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

The acute phase of the COVID-19 pandemic requires a redefinition of healthcare system to increase the number of available intensive care units for COVID-19 patients. This leads to the postponing of elective surgeries including the treatment of abdominal aortic aneurysm (AAA). The probabilistic rupture risk index (PRRI) recently showed its advantage over the diameter criterion in AAA rupture risk assessment. Its major improvement is in increased specificity and yet has the same sensitivity as the maximal diameter criterion. The objective of this study was to test the clinical applicability of the PRRI diagnostic method in a quasi-prospective observational patient cohort study.

Conditions

• Abdominal Aortic Aneurysm
• COVID-19

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Biomechanical rupture risk assessment	3D computational model is created from CT angiographic images available during standard AAA diagnostic process. Vascular wall stress is assessed based on the 3D model using Finite element method to identify highly stressed parts of AAA and results are compared to populational wall strength information (gathered from previous large histological study), thus rupture risk (stress/strength ratio) of each particular AAA is estimated. Other relevant factors such as gender, blood pressure, presence of intraluminal thrombus etc. are used during the calculation as well.

Timeline

• Start date: 2020-03-12
• Primary completion: 2021-12-17
• Completion: 2022-03-01
• First posted: 2022-01-19
• Last updated: 2022-01-25

Locations

1 site across 1 country: Czechia