NCT05196698

Home High Flow Oxygen to Reduce Acute Exacerbation of COPD

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 406 (estimated)
• Sponsor: University Hospital, Rouen · Academic / Other
• Sex: All
• Age: 18 Years – 85 Years
• Healthy volunteers: Not accepted

Summary

The objective of the study is to evaluate the efficacy of home High Flow Oxygen for the reduction of severe exacerbation following admission for a severe exacerbation of COPD or death against standard oxygen therapy.

Conditions

• Chronic Obstructive Pulmonary Disease

Interventions

Type	Name	Description
OTHER	High Flow Oxygen Therapy	HFOT will be delivered validated medical devices and established as follow: * Patient will be acclimatized to HFOT which will aim to achieve a flow of air of 30L/min at a temperature of 34°C using dedicated nasal canula. * Once patient acclimatized, oxygen will be entrained in the HFOT device at a flow that will aim to achieve a saturation \> 90%. An arterial blood gas will be performed with such oxygen delivery, flowrate and temperature to ensure a PaO2 ≥ 8kPa
OTHER	Long-term oxygen therapy	LTOT delivery will be performed according to French guidelines

Timeline

• Start date: 2022-08-26
• Primary completion: 2026-08-26
• Completion: 2026-08-26
• First posted: 2022-01-19
• Last updated: 2026-02-06

Locations

1 site across 1 country: France