NCT05195268

Reduction in Arrhythmia Burden With Left Atrial Posterior Wall Ablation for Persistent AF

• Status: Withdrawn
• Phase: N/A
• Study type: Interventional
• Enrollment: 0 (actual)
• Sponsor: Liverpool Heart and Chest Hospital NHS Foundation Trust · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

RABLAP-AF will compare pulmonary vein isolation (PVI) in combination with posterior wall isolation (PWI) for patients with persistent atrial fibrillation (AF).

Detailed description

Ablation for AF has a high success rate for patients with paroxysmal AF, but success rates for persistent AF remain significantly lower. These patients frequently have more advanced disease in their left atrium than those with paroxysmal AF. A common practice is to perform left atrial PWI in addition to PVI in order to reduce AF recurrence. This approach has conflicting evidence behind it and a large scale clinical trial in those with advanced disease is required. The investigators hope to fill this gap with RABLAP-AF. The investigators will randomise patients with advanced atrial disease 1:1 to PVI+PWI or PVI alone. All patients will receive implantable loop recorders two months prior to the ablation procedure in order to accurately assess the effect of PWI and compare arrhythmia burden before and after ablation.

Conditions

• Atrial Fibrillation

Interventions

Type	Name	Description
PROCEDURE	Intracardiac Catheter Ablation	Both arms will receive intracardiac catheter ablation procedures as described.

Timeline

• Start date: 2022-07-01
• Primary completion: 2022-09-12
• Completion: 2022-09-12
• First posted: 2022-01-18
• Last updated: 2022-09-29

Locations

1 site across 1 country: United Kingdom