NCT05195177

Testing Protocol to Efficiently Induce Itch

Nerve Excitability Testing Protocol to Efficiently Induce Itch

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (estimated)
• Sponsor: Aalborg University · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Accepted

Summary

This subproject aims to evaluate a new nerve excitability protocol to induce itch in healthy controls by electrical stimulation. Itch has many similarities with pain, and the nerve fibers that mediate the two sensations probably have the same morphological and excitability properties. The method used in this project will be the same as our research group uses for studying nociceptor fibers (PTT technique), but the focus is on the itch sensation. Since the itch fibers also terminate in the epidermis, our PTT technique should also be able to activate itch fibers, similar to pain fibers. If itch could be effectively induced by electrical stimulation, this would generate a valuable tool for studying itch in healthy controls. The sub-project takes place in 2 sessions (2 hours each).

Conditions

• Itch

Interventions

Type	Name	Description
DRUG	Anti-histamine cream 1 hour	At the start of session 1, one area of the middle forearms of the participant will be located (4x4cm). On the area, anti-histamine cream will be applied for approximately 1 hour.
DRUG	Local anesthetic cream 1 hour	At the start of session 2, one area of the middle forearms of the participant will be located (4x4cm). On the area, local anesthetic cream (2.5% lidocain/2.5 prilocaine) will be applied for approximately 1 hour.

Timeline

• Start date: 2021-11-25
• Primary completion: 2023-12-20
• Completion: 2023-12-20
• First posted: 2022-01-18
• Last updated: 2023-08-02

Locations

1 site across 1 country: Denmark