NCT05193786

Low Versus High PEEP in Noninvasive Ventilation for Hypoxemic Respiratory Failure

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 380 (actual)
• Sponsor: Chongqing Medical University · Academic / Other
• Sex: All
• Age: 16 Years – 85 Years
• Healthy volunteers: Not accepted

Summary

Current study aimed to explore the effect of high PEEP during noninvasive ventilation among hypoxemic patients with acute respiratory failure.

Detailed description

This was a 1:1 randomized control trial to explore the effect of high versus low PEEP in noninvasive ventilation hypoxemic patients with acute respiratory failure. Several ICUs in China performed this study. In the high PEEP group, the PEEP maintained at 10-15 cmH2O, the inspiratory pressure maintained at 15-20 cmH2O. In the low PEEP group, the PEEP maintained at 5 cmH2O, the inspiratory pressure maintained at 10-20 cmH2O. The primary outcome was incidence of noninvasive ventilation failrue.

Conditions

• Noninvasive Ventilation

Interventions

Type	Name	Description
PROCEDURE	Different level of PEEP	Different level of PEEP (low versus high) was applied in noninvasive ventilation.

Timeline

• Start date: 2022-01-11
• Primary completion: 2024-08-31
• Completion: 2024-08-31
• First posted: 2022-01-18
• Last updated: 2025-01-24

Locations

1 site across 1 country: China