NCT05184699

The Effect of Dietary Intervention on Endothelial Glycocalyx in Psoriasis

The Effect of Dietary Intervention on Endothelial Glycocalyx Integrity and Microvascular Perfusion in Patients With Psoriatic Disease

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (estimated)
• Sponsor: University of Athens · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

The food supplement Endocalyx is considered to support the endothelial glycocalyx integrity by supplying sulfated polysaccharides, anti-oxidant enzymes and additional substrates for glycocalyx synthesis. The investigators will study the effect of Endocalyx on endothelial, vascular and left ventricular myocardial function in patients with psoriatic disease.

Detailed description

Sixty patients with psoriatic disease, who are referred to the outpatient psoriasis clinic of the Attikon University Hospital, will be randomized to receive food supplement Endocalyx (4 capsules per day) (n=30) or placebo (n=30) for 4 consecutive months.

Conditions

• Psoriasis

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Food supplement Endocalyx	Patients with psoriatic disease will be randomized to receive food supplement Endocalyx for 4 months.
DIETARY_SUPPLEMENT	Placebo	Patients with psoriatic disease will be randomized to receive placebo for 4 months.

Timeline

• Start date: 2022-11-01
• Primary completion: 2023-11-01
• Completion: 2024-01-30
• First posted: 2022-01-11
• Last updated: 2023-05-16

Locations

1 site across 1 country: Greece