NCT05183373

Inflammation and Clotting Abnormalities in Aneurysmal Coronary Artery Disease

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 180 (estimated)
• Sponsor: John Paul II Hospital, Krakow · Academic / Other
• Sex: All
• Age: 18 Years – 85 Years
• Healthy volunteers: Not accepted

Summary

The main objective of the CARE-ANEURYSM project is to evaluate inflammation and clotting abnormalities in patients with aneurysmal coronary artery disease in relation to patients with abdominal aortic aneurysm or coronary artery disease (acting as controls).

Detailed description

The trial will enrol 180 patients, 60 in each of three groups: 1) aneurysmal coronary artery disease; 2) abdominal aortic aneurysm; 3) coronary artery disease. In addition, up to 250 patients with aneurysmal coronary disease will be follow for clinical outcomes in relation to controls (prognosis group). The primary research question of this project is to evaluate wheter the inflammation and clotting abnormalities in patients with aneurysmal coronary artery disease differ from ones in abdominal aortic aneurysm or coronary artery diseases. Study endpoints include the level of inflammation biomarkers and fibrin clot properties in each cohort.

Conditions

• Coronary Artery Aneurysm
• Abdominal Aortic Aneurysm
• Coronary Disease

Interventions

Type	Name	Description
OTHER	Evaluation of inflammation and clotting	Evaluation of inflammation biomarkers (such as 8-isoprostane, Il-6) and fibrin clot properties (such as clot lysis time, clot permeability)

Timeline

• Start date: 2022-01-10
• Primary completion: 2024-09-30
• Completion: 2025-09-30
• First posted: 2022-01-10
• Last updated: 2022-01-10

Locations

1 site across 1 country: Poland