NCT05181059

DLSCT for Breast Cancer Detection in Women With Dense Breasts

Dual-layer Spectral Computerized Tomography for Breast Cancer Detection in Women With Dense Breasts: a Single Centre, Feasibility Study - The DECREAS Study

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 14 (estimated)
• Sponsor: Rijnstate Hospital · Academic / Other
• Sex: Female
• Age: 18 Years
• Healthy volunteers: —

Summary

The main objective of this project is to demonstrate the feasibility of DLSCT to detect breast cancer in women with dense breasts. Patients with locoregional advanced primary breast cancer and heterogeneously (n = 7) or extremely dense breasts (n = 7) as determined by mammography will be included in this study. These patients have an indication for a positron emission tomography computed tomography (PET-CT) scan to search for distant metastases. In this study the participants will undergo an additional contrast enhanced DLSCT scan to determine the feasibility of spectral CT to detect breast cancer in women with dense breasts.

Conditions

• Breast Neoplasms
• Breast Density
• Radiographic Image Interpretation, Computer-Assisted

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Dual-layer spectral computerized tomography (DLSCT)	Contrast enhanced DLSCT scan using a 128-slice dual-layer detector (IQon Spectral CT, Philips Health Systems) will be performed. Patients will be placed in prone position during the DLSCT scan in order to improve the visualisation of breast tissue and comparability with MRI images. During the examination we will administer a nonionic low-osmolar iodinated contrast agent (Optiray©) in order to visualise tumor angiogenesis.

Timeline

• Start date: 2022-01-01
• Primary completion: 2023-01-01
• Completion: 2023-01-01
• First posted: 2022-01-06
• Last updated: 2022-01-06

Locations

1 site across 1 country: Netherlands