NCT05178953

The Therapeutic Effect of Co-administration of Pentoxifylline and Zinc in Men With Idiopathic Asthenozoospermia

The Therapeutic Effect of Co-administration of Pentoxifylline and Zinc on Semen Parameters, Reproductive Hormones, DNA Fragmentation, and Some Biochemical, and Inflammatory Parameters in Men With Idiopathic Infertility

• Status: Unknown
• Phase: EARLY_Phase 1
• Study type: Interventional
• Enrollment: 160 (estimated)
• Sponsor: Arak University of Medical Sciences · Academic / Other
• Sex: Male
• Age: 23 Years – 45 Years
• Healthy volunteers: Accepted

Summary

The aim of this study was to investigate the therapeutic effect of co-administration of pentoxifylline and zinc on sperm apoptosis in men with idiopathic infertility

Detailed description

This study is being performed as a double-blind randomized clinical trial on idiopathic infertile men referred to the infertility clinic of Shafa Clinic. Patient satisfaction, non-use of contraceptives, men aged 25 to 43 years, and idiopathic infertility according to WHO criteria (World Health, 2010) are our study criteria. Any medication that may affect the course of spermatogenesis should be discontinued during the study. Semen samples are taken from patients (before and after interventions) and apoptosis tests are performed on semen samples.

Conditions

• Men Infertility

Interventions

Type	Name	Description
DRUG	Zinc Sulfate 220 mg Capsules	Zinc is an element that is involved in the activity of antioxidant enzymes. For example, the superoxide dismutase needs copper and zinc to function properly. Infertile men with asthenospermia receive 220 mg zinc sulfate tablets for 3 months
DRUG	Pentoxifylline	Oral use of pentoxifylline is effective in treating cardiovascular disease, cerebrovascular disease, and other conditions associated with local circulatory disorders. Pentoxifylline affects blood viscosity. Infertile men with asthenospermia receive 400 mg pentoxifylline tablets for 3 months

Timeline

• Start date: 2021-08-01
• Primary completion: 2022-01-08
• Completion: 2022-01-20
• First posted: 2022-01-05
• Last updated: 2022-01-05

Locations

2 sites across 1 country: Iran