NCT05172570

Gabapentin Dosages for Postoperative Analgesia Following Open Thoracotomy

Randomized Prospective Study Comparing Variable Gabapentin Dosages for Postoperative Analgesia Following Open Thoracotomy

• Status: Terminated
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 20 (actual)
• Sponsor: Indiana University · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

Gabapentin is a nerve medication that treats pain. The specific aim of the study is to compare the difference in the postoperative use of no gabapentin, 300 mg gabapentin 3x daily, or 300 mg gabapentin once at night. Our hypothesis is that higher doses of gabapentin will correlate with decreased pain at the incision and chest tube sites and decreased opioid consumption.

Detailed description

The purpose of this study is to determine the effectiveness of various dosages of gabapentin, as part of an ERAS protocol, for postoperative analgesic control after open thoracotomy and additionally determine if there is a correlation of the dosage of gabapentin with pulmonary complication and impaired cognition postoperatively. Given the widespread use of gabapentin and the huge variability in dosing, our study aims to simplify ERAS protocols for thoracotomy by figuring out the optimal dosing of gabapentin and whether its use overall decreases postoperative opioid consumption and complications. The specific aim of the study is to compare the difference in the postoperative use of no gabapentin, 300 mg gabapentin 3x daily, or 300 mg gabapentin once at night.

Conditions

• Thoracotomy
• Pain, Postoperative

Interventions

Type	Name	Description
DRUG	Gabapentin	Gabapentin is a common medication used preoperatively and postoperatively as part of multimodal analgesia to help with acute pain.

Timeline

• Start date: 2021-04-06
• Primary completion: 2022-02-25
• Completion: 2022-03-02
• First posted: 2021-12-29
• Last updated: 2024-03-21
• Results posted: 2024-03-21

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study