NCT05169333

The Oxford Risk Factors And Non-Invasive Imaging Study

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 250,000 (estimated)
• Sponsor: University of Oxford · Academic / Other
• Sex: All
• Age: 18 Years – 99 Years
• Healthy volunteers: Not accepted

Summary

ORFAN is a prospective, multi-centre, multi-ethnic cohort observational study collecting CT scans, biological material and outcomes data, to develop and validate novel biomarkers of cardiometabolic and other disease risk.

Detailed description

The ORFAN registry will include unselected, consecutive patients undergoing CT scans (coronary CT angiograms (CCTA), CT chest, abdomen and pelvis scans) collected at the participating centres. The study will combine imaging data with patient demographics and clinical information (including prospective outcomes) to aid the development and/or validation of new or existing image analysis algorithms and software tools to improve diagnosis, clinical risk discrimination and prediction. Specifically, ORFAN will evaluate the specificity, utility and predictive value of newly developed image analysis methods. ORFAN will recruit and follow-up patients prospectively, linking the index CT scan with blood biomarkers, genetic information as well as information on disease progression (recorded through follow-up CT scans) and clinical outcomes data. The study will also collect CT scans performed in the past and link them with clinical factors and prospective outcomes data collected after the index scan was performed.

Conditions

• Cardiovascular Diseases
• Cardiovascular Risk Factors

Timeline

• Start date: 2016-02-23
• Primary completion: 2030-02-01
• Completion: 2030-02-01
• First posted: 2021-12-23
• Last updated: 2024-12-11

Locations

37 sites across 15 countries: United States, Australia, Belgium, China, France, Germany, Greece, Hungary, Italy, Japan, Netherlands, Romania, South Korea, United Arab Emirates, United Kingdom