NCT05167942

Exploration of the Deep Transcranial Magnetic Stimulation for Treatment Resistant Schizophrenia

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 87 (estimated)
• Sponsor: Shanghai Mental Health Center · Academic / Other
• Sex: All
• Age: 18 Years – 50 Years
• Healthy volunteers: Not accepted

Summary

Negative symptoms and cognitive dysfunction are of importance for the prognosis of the patients of schizophrenia. Based on the hypothesis that deep transcranial magnetic stimulation(dTMS) on prefrontal cortex #PFC# could down-regulate the glutamate level of PFC and regulate the functional network in patients with treatment resistance schizophrenia,this research plan to utilise multimodal functional magnetic imaging method(including structural MRI,resting-state functional magnetic resonance imaging and 1H-MRS) to investigate therapeutic efficacy of high-frequency deep transcranial magnetic stimulation on SZ patients symptoms,as well as to elucidate the correlation between treatment effects and glutamate level of PFC

Detailed description

This study includes 87 treatment resistance schizophrenia patients. This study will investigate 1)abnormalities of the glutamate level of PFC in patients with schizophrenia compared to healthy controls by using 1H-MRS technique. 2)potential modulation effects of deep transcranial magnetic stimulation(dTMS) on prefrontal cortex function of patients with schizophrenia. 3)the therapeutic efficacy of dTMS on cognitive impairments and other psychotic symptoms of patients with schizophrenia by adopting cognitive function and psychotic symptoms evaluation,as well as to explore the optimal dTMS treatment pattern on cognitive function.

Conditions

• Treatment Resistant Schizophrenia Based on the DTMS

Interventions

Type	Name	Description
DEVICE	deep transcranial magnetic stimulation with H1 coil	Sham deep transcranial magnetic stimulation on PFC .Duration:40 days.
DEVICE	High frequency deep transcranial magnetic stimulation with H1 coil	high frequency(20Hz) deep transcranial magnetic stimulation on PFC .Duration:40 days.
DEVICE	iTBS deep transcranial magnetic stimulation with H1 coil	iTBS deep transcranial magnetic stimulation on PFC .Duration:40 days.

Timeline

• Start date: 2021-11-01
• Primary completion: 2023-09-01
• Completion: 2023-09-30
• First posted: 2021-12-22
• Last updated: 2021-12-22

Locations

1 site across 1 country: China