NCT05167591

Detection of Paracetamol Concentration in Patients Using Regular Medication- a Validation Study for a Novel Technique

Determination of Serum Paracetamol Concentration With an Electrochemical Measurement Tool From Blood and Saliva Samples in Patients Using Also Other Medication.

• Status: Withdrawn
• Phase: N/A
• Study type: Interventional
• Enrollment: 0 (actual)
• Sponsor: Johanna Kujala · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

Paracetamol intoxication is common, and concentration measurements are performed regularly. This research group is developing a fast bedside electrochemical analysis tool for paracetamol concentration measurement. This study will find out how this novel method performs in patients using other, confounding medication in detecting paracetamol concentration in capillary blood, venous plasma and saliva samples.

Detailed description

Paracetamol concentration analysis is performed in 20 patients who will come to hospital for elective surgery. Inclusion criteria is a regular medication that continues over perioperative period. Patients will be given standard premedication of paracetamol 1g perorally before surgery: this study does not affect standard surgical treatment. Paracetamol concentration will be measured in venous plasma-, capillary blood-, and saliva samples before drug delivery and in recovery room after surgery using the novel electrochemical analysis tool and high-performance mass spectrometry analysis as a reference. If needed, confounding medication is identified with large toxicologic mass spectrometry screen (UPLC-QTOF).

Conditions

• Pharmacokinetics

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Drug concentration measurement	Measurement of paracetamol concentration in capillary, venous plasma and saliva samples after standard premedication with paracetamol

Timeline

• Start date: 2024-03-01
• Primary completion: 2024-03-04
• Completion: 2024-03-04
• First posted: 2021-12-22
• Last updated: 2024-03-06