NCT05167552

Treatment of Allergic Rhinitis and Chronic Polypous Rhinosinusitis With Olfactory Mucosa-derived Mesenchymal Stem Cells

Treatment of Patients With Allergic Rhinitis and Chronic Polypous Rhinosinusitis With Olfactory Mucosa-derived Mesenchymal Stem Cells

• Status: Unknown
• Phase: Phase 1 / Phase 2
• Study type: Interventional
• Enrollment: 60 (estimated)
• Sponsor: Institute of Biophysics and Cell Engineering of National Academy of Sciences of Belarus · Other Government
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

Treatment of patients with allergic rhinitis and chronic polypous rhinosinusitis with olfactory mucosa-derived mesenchymal stem cells

Detailed description

During the implementation of the project, the methods for the treatment of allergic rhinitis and chronic polypous rhinosinusitis with olfactory mucosa-derived mesenchymal stem cells will be developed. The positive outlook for the effectiveness of MSCs is due to the following: * knowledge of the leading role of immunopathogenetic mechanisms in the development of allergic rhinitis and chronic polypous rhinosinusitis and the pronounced immunomodulating properties of MSCs; * the ability of MSCs to reduce the production of proinflammatory cytokines and suppress immune inflammation; * positive results of preclinical studies of the method of treatment of diseases accompanied by over-activation of the immune system, including autoimmune diseases, in animals and the first clinical studies in patients.

Conditions

• Allergic Rhinitis
• Rhinosinusitis Chronic

Interventions

Type	Name	Description
BIOLOGICAL	Olfactory mucosa-derived mesenchymal stem cells	Olfactory mucosa-derived mesenchymal stem cells
OTHER	Standard treatment of type Allergic Rhinitis according to the clinical protocols	Standard treatment of type Allergic Rhinitis according to the clinical protocols
OTHER	Standard treatment of type Chronic Polypous Rhinosinusitis according to the clinical protocols	Standard treatment of type Chronic Polypous Rhinosinusitis according to the clinical protocols

Timeline

• Start date: 2022-03-01
• Primary completion: 2023-12-31
• Completion: 2023-12-31
• First posted: 2021-12-22
• Last updated: 2022-01-19