NCT05164146

The Comparison of Hypotension Incidence Between Remimazolam and Propofol in Hypertensive Patients Undergoing Neurosurgery

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 100 (actual)
• Sponsor: Yonsei University · Academic / Other
• Sex: All
• Age: 19 Years – 75 Years
• Healthy volunteers: Accepted

Summary

This study aims to find an excellent drug in terms of hemodynamic stability when comparing the propofol and remifentanil with the combined use of remimazolam and remifentanil. When the mean blood pressure falls by 20% or more from the baseline mean blood pressure, it is considered hypotension, and a vasopressor such as ephedrine, phenylephrine, or norpin is used to control the blood pressure to within 20% of the baseline blood pressure. If the blood pressure increases by 20% or more above the baseline mean blood pressure, nicardipine infusion or remimazolam, propofol or remifentanil should be increased to control the blood pressure.

Conditions

• Patients Undergoing Neurosurgery

Interventions

Type	Name	Description
DRUG	propofol	during the induction, remimazolam dose was controlled according to sedline (Psi target 40)
DRUG	remimazolam	During induction, remimazolam dose was controlled according to sedline (Psi target 40)

Timeline

• Start date: 2022-02-23
• Primary completion: 2022-08-10
• Completion: 2022-08-10
• First posted: 2021-12-20
• Last updated: 2022-11-07

Locations

1 site across 1 country: South Korea