NCT05163366

Oral Morphine Versus Ketamine in Pain Management

Oral Morphine Versus Rectal Ketamine in Pain Management During Burns Wound Dressing Changes in Paediatric Population at Mbarara Regional Referral Hospital: An Open Label Randomized Trial

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 44 (actual)
• Sponsor: Mbarara University of Science and Technology · Academic / Other
• Sex: All
• Age: 6 Months – 6 Years
• Healthy volunteers: Accepted

Summary

The study will mainly focus on procedural pain management using oral morphine versus rectal ketamine during paediatric burn and wound dressing at Mbarara Regional Referral Hospital.

Detailed description

Subjects will be randomly assigned to one of the two treatment groups A and B. Guardians of patients who are scheduled for burn wound care will sign written consent pre- operatively about procedural pain management. Group A will receive rectal ketamine while those in Group B will receive only traditional standard of care protocols.

Conditions

• Pain, Procedural

Interventions

Type	Name	Description
DRUG	GROUP A	Rectal Ketamine will be administered at 6 mg/kg and with a rectal nozzle it's infused through the rectum. The rectal ketamine will be administered after scoring pain just before the start of the procedure and then about 15 minutes later the procedure will start when the patient has achieved a nystagmus.
DRUG	GROUP B	The tradition standard protocols involve the use of 0.3mg/kg of oral morphine about an hour before the start of the procedure before the start of the procedure to allow for the onset of action of oral morphine for every single procedure in this arm.

Timeline

• Start date: 2021-03-01
• Primary completion: 2021-11-03
• Completion: 2021-11-03
• First posted: 2021-12-20
• Last updated: 2021-12-20

Locations

2 sites across 1 country: Uganda