NCT05162391

Inflammation in Methamphetamine and STIs (IMSTI)

Effects of Methamphetamine Use on Risk Behavior, Systemic and Mucosal Inflammation, and Sexually Transmitted Infection (STI)/HIV Risk Among Men Who Have Sex With Men

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (estimated)
• Sponsor: University of California, Los Angeles · Academic / Other
• Sex: Male
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

This clinical trial aims to investigate the effects of a decline in methamphetamine use on rectal inflammatory cytokine levels, substance use contexts, and HIV/STI risk behavior. This clinical trial also seeks to evaluate joint effects of methamphetamine use and rectal gonorrhea/chlamydia infection on rectal inflammatory cytokine levels. The proposed trial will consist of 40 MSM, half with rectal gonorrhea/chlamydia infection at enrollment (n=20), with methamphetamine use disorder that will receive contingency management for methamphetamine reduction. Following baseline measurement, participants will be observed over the course of 8 weeks, where participants will complete behavioral surveys, provide urine for drug testing, and rectal samples for measurement of rectal inflammatory cytokine levels.

Conditions

• Methamphetamine-dependence
• Rectal Gonorrhea
• Rectal Chlamydia

Interventions

Type	Name	Description
BEHAVIORAL	Contingency Management	Contingency management intervention with incentives tied to provision of urine samples with no detectable levels of methamphetamine (MA).

Timeline

• Start date: 2022-05-31
• Primary completion: 2026-06-30
• Completion: 2027-06-30
• First posted: 2021-12-17
• Last updated: 2025-05-15

Locations

1 site across 1 country: United States