NCT05158309

Measuring and Modulating Changes in EEG Resting State Functional Connectivity During Short-term and Long-term Pain

Aalborg University, Aalborg, Denmark

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 24 (actual)
• Sponsor: Aalborg University · Academic / Other
• Sex: All
• Age: 19 Years – 44 Years
• Healthy volunteers: Accepted

Summary

Background and aims: Experimental prolonged pain models can shed more light on the cortical mechanisms involved in the transition from acute to chronic pain including changes in resting state functional connectivity (rsFC). This experiment aimed at examining the effect of 24-hour-capsaicin application on the rsFC of the default mode network (DMN), a prominent network in the dynamic pain connectome. Methods: Electroencephalographic (EEG) rsFC measured by Granger causality was acquired at baseline, 1-hour, and 24-hour following the initial patch application (placebo or capsaicin). After 24 hours, the patch was cooled down then heated up to assess rsFC changes in response to pain relief and facilitation. Pain was induced using a topical capsaicin patch (or placebo as control) on the right forearm and assessed on a 0-10 numerical rating scale (NRS).

Conditions

• Prolonged Pain, EEG, Resting State Functional Connectivity

Interventions

Type	Name	Description
OTHER	8% Capsaicin patch	Cutaneous pain was induced using a (5x10 cm) 8% topical capsaicin patch (transdermal patch, 'Qutenza', Astellas) on the volar part of the dominant right forearm (5 cm from the wrist) of each participant.
OTHER	placebo patch	A transparent patch with no formulation or effect but the same size of the capsaicin patch was applied to the same location.

Timeline

• Start date: 2021-05-31
• Primary completion: 2021-11-06
• Completion: 2021-11-06
• First posted: 2021-12-15
• Last updated: 2022-03-15

Locations

1 site across 1 country: Denmark