NCT05158153

Outpatient Recovery From Acute Kidney Injury Requiring Dialysis

• Status: Terminated
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 1 (actual)
• Sponsor: University of California, San Francisco · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

There are currently no therapies to improve the chances of recovering enough kidney function to come off of dialysis after severe acute kidney injury. It is not known if current routine outpatient dialysis treatments are optimized to maximize the chances of recovery. The purpose of this pilot study is to see if we can feasibly and safely provide several changes to the way that dialysis is provided in outpatient dialysis centers which may improve the chances of recovery.

Conditions

• Acute Kidney Injury
• Dialysis Hypotension

Interventions

Type	Name	Description
OTHER	ORKID Bundled Intervention	During the 90-day study period, participants will be prescribed outpatient hemodialysis with cooled dialysate (35-36°C), high sodium dialysate (145 mmol/L), a high ultrafiltration hold threshold (systolic blood pressure \> 110 mmHg; ultrafiltration hold threshold will not be applied in participants with baseline systolic blood pressure \< 120 mmHg), and high dose diuretics (160 mg oral furosemide twice daily) to be taken every day at home will also be prescribed. Dialysis will be weaned according to an active weaning protocol.
DRUG	Furosemide	160 mg oral furosemide twice daily to be taken every day at home

Timeline

• Start date: 2021-10-18
• Primary completion: 2022-04-19
• Completion: 2022-04-19
• First posted: 2021-12-15
• Last updated: 2023-05-12
• Results posted: 2023-05-12

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study