NCT05156437

Postoperative Antibiotic Management Duration Following Surgery for Intravenous Drug Abuse (IVDA) Endocarditis (OPTIMAL)

• Status: Enrolling By Invitation
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 20 (estimated)
• Sponsor: Vinay Badhwar · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to determine the safety and compliance of initial intravenous (IV) antibiotics followed by oral antibiotic therapy following uncomplicated IVDA endocarditis. Endocarditis has a high rate of sickness and death, involves a long hospitalization and a long-term use of IV antibiotics necessitating six (6) weeks of in-patient hospital stay, and comes with a high cost.

Conditions

• Endocarditis

Interventions

Type	Name	Description
DRUG	Amoxycillin, Cefalexin, Dicloxacillin, Linezolid, Levofloxacin, Rifampicin	Amoxycillin, Cefalexin, Dicloxacillin, Linezolid, Levofloxacin, Rifampicin
DRUG	Ampicillin, Oxacillin, Vancomycin, Daptomycin, Ceftriaxone, Cefepime, Ceftaroline	Ampicillin, Oxacillin, Vancomycin, Daptomycin, Ceftriaxone, Cefepime, Ceftaroline

Timeline

• Start date: 2022-03-16
• Primary completion: 2024-10-01
• Completion: 2024-10-01
• First posted: 2021-12-14
• Last updated: 2023-12-07

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study