NCT05155358

Study on the Establishment of a System for Early Warning and Prognostic Evaluation of Patients With Heat Stroke

• Status: Not Yet Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 150 (estimated)
• Sponsor: Xijing Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 90 Years
• Healthy volunteers: Accepted

Summary

Heat stroke is a clinical syndrome with high incidence and high fatality rate in summer. Patients with liver, kidney, and brain damage are prone to secondary MODS, and the prognosis is poor due to high medical costs. At present, there is no unified diagnostic criteria for acute liver injury associated with heat stroke, and the commonly used prognosis scores are rarely included in liver injury indicators, which is not good for practicality.

Detailed description

The project intends to collect the peripheral blood of the normal population, the 24 hours after the onset of heat stroke and the patients in the recovery period, to separate and extract plasma, PBMC, and plasma exosomal miRNA, and sequence to search for indicators related to disease deterioration and prognosis, construct and verify the early warning and prognosis evaluation system of the disease. On this basis, the researcher explore cellular and molecular mediated pathological mechanisms of heat stroke, and then clarify the treatment target of heat stroke.

Conditions

• Heat Stroke
• Early Waking
• MODS
• Proteinosis
• Liver Injury
• Kidney Injury

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Peripheral blood test	Collect peripheral blood to separate and extract plasma, PBMC, and plasma exosomal miRNA, and sequence to find indicators related to disease deterioration and prognosis

Timeline

• Start date: 2025-08-31
• Primary completion: 2027-06-30
• Completion: 2027-12-31
• First posted: 2021-12-13
• Last updated: 2025-08-14

Locations

1 site across 1 country: China