NCT05153837

Effect of Oral Water in Healthy Volunteers on Cardiac Output, Regional Flow and Microcirculation in Healthy Volunteers

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 59 (actual)
• Sponsor: Centre Hospitalier Universitaire, Amiens · Academic / Other
• Sex: All
• Age: 18 Years – 30 Years
• Healthy volunteers: Accepted

Summary

Human digestive system physiologically ensures the absorption of oral water and hydration of the human body. Water is quickly absorbed by the digestive tract with a peak between 15 and 20 minutes. It has demonstrated that oral water remains the best hydration solution that have an effect on plasma volume expansion and cardiovascular system during exercise. While the cardiovascular effect of fluid expansion by saline serum is well known (venous return, preload and cardiac output), effect of oral water varies in the literature depending on the physiological state of the patient and the clinical state. Thus, the investigators aim to investigate oral water effects on fluid responsiveness, regional blood flow and microcirculatory changes.

Conditions

• Intravenous Fluids
• Pharmacodynamics
• Fluid Therapy
• Fluid Responsiveness
• Fluid Challenge

Interventions

Type	Name	Description
OTHER	saline intravenous administration	Administration of 500 mL of saline (NaCl 0.9%) administered by the venous route
OTHER	oral water	500 ml oral water

Timeline

• Start date: 2021-11-30
• Primary completion: 2023-08-28
• Completion: 2023-08-28
• First posted: 2021-12-10
• Last updated: 2025-05-28

Locations

1 site across 1 country: France