NCT05149716

Taurine as a Possible Anti-aging Therapy?

Taurine as a Possible Anti-aging Therapy? A Controlled Clinical Trial on Taurine Antioxidant Activity in Women Aged 55 to 70 Years

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 24 (actual)
• Sponsor: University of Sao Paulo · Academic / Other
• Sex: Female
• Age: 55 Years – 70 Years
• Healthy volunteers: Accepted

Summary

Among the strategies that can improve the body's ability to counteract oxidative stress, the use of nutritional antioxidants has been investigated. Taurine is a "semi-essential" amino acid, also called a nitrogen compound, which has been used as an effective antioxidant due to its ability to neutralize hypochlorous acid, an extremely toxic oxidant produced by leukocytes in the inflammatory process in humans.

Detailed description

Objective: To evaluate the oxidative parameters of women aged 55 to 70 years after 16 weeks of taurine supplementation. Methods: Twenty-four women age 55 to 70 will be randomly assigned to two groups: control group (GC), supplemented with placebo (1.5 g of starch); and taurine group (GTAU), supplemented with taurine (1.5 g), for 16 weeks. Anthropometry, functional capacity test, taurine, and levels of oxidative stress markers will be determined in pre and post intervention plasma samples. Food consumption will be assessed before, during, and after the intervention. The results will be analyzed by an ANOVA two-way repeated measures mixed model, with the Sidak post hoc (p \< 0.05).

Conditions

• Oxidative Stress

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Taurine	Taurine supplementation in capsules of 500 grams of taurine powder, total dosage: 1.5 gram/day
DIETARY_SUPPLEMENT	Placebo	Placebo supplementation in capsules of 500 grams of starch powder, total dosage: 1.5 gram/day

Timeline

• Start date: 2020-01-13
• Primary completion: 2020-06-15
• Completion: 2020-07-03
• First posted: 2021-12-08
• Last updated: 2021-12-08

Locations

1 site across 1 country: Brazil