NCT05149547

mNGS Versus Blood Culture in FN

The Comparison of mNGS Versus Blood Culture for Early Diagnosis of Blood Stream Infection During the Febrile Neutropenia in Patients With Hematological Disease

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 300 (estimated)
• Sponsor: Peking University People's Hospital · Academic / Other
• Sex: All
• Age: 15 Years
• Healthy volunteers: —

Summary

Blood stream infection (BSI) during febrile neutropenia (FN) is a lethal complication, while confirmed diagnosis via blood culture is usually with low sensitivity and time delay. The new technique of metagenome next generation sequencing (mNGS) has the potential of early and more accurate detection of pathogens. However, this technique has not been well validated for BSI diagnosis in patients with hematological disease. Therefore, we designed a prospective multicenter study to compare the diagnosis performance in BSI.

Conditions

• Infections
• Hematologic Diseases
• Febrile Neutropenia

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	blood culture versus mNGS detection	peripheral 4ml for mNGS detection

Timeline

• Start date: 2021-10-15
• Primary completion: 2022-05-31
• Completion: 2022-08-31
• First posted: 2021-12-08
• Last updated: 2021-12-08

Locations

1 site across 1 country: China