NCT05147649

Functional Magnetic Resonance Imaging in Patients With Obstructive Sleep Apnea Syndrome

Functional Magnetic Resonance Imaging in Patients With Obstructive Sleep Apnea Syndrome, With and Without CPAP, During Wakefulness - Impact on Cognitive Functions

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 70 (estimated)
• Sponsor: CHU de Reims · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Accepted

Summary

The obstructive sleep apnea syndrome (OSAS) involves recurrent sleep-related upper airways (UA) collapse. UA mechanical properties and neural control are altered, imposing a mechanical load on inspiration. UA collapse does not occur during wakefulness, hence arousal-dependent compensation. Experimental inspiratory loading in normal subjects elicits respiratory-related cortical activity during wakefulness. The objective of this study is to test whether awake OSAS patients would exhibit a similar cortical activity. Whether or not such cortical compensatory mechanisms have cognitive consequences would be also analyze.

Conditions

• Obstructive Sleep Apnea Syndrome

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	functional magnetic resonance imaging	functional magnetic resonance imaging

Timeline

• Start date: 2023-03-02
• Primary completion: 2027-01-02
• Completion: 2027-07-02
• First posted: 2021-12-07
• Last updated: 2025-12-02

Locations

1 site across 1 country: France