NCT05147103

Investigation of the Duration of Low-intensity Focused Ultrasound

• Status: Enrolling By Invitation
• Phase: N/A
• Study type: Interventional
• Enrollment: 80 (estimated)
• Sponsor: Virginia Polytechnic Institute and State University · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

This project examines the effects of various durations of noninvasive neuromodulation on muscle contractions. The investigators believe this study will help to better understand noninvasive brain stimulation techniques that may have the potential to aid in addiction, pain, and mental health issues. Participants undergo structural imaging, a functional Magnetic Resonance Image (fMRI) and computed tomography (CT). These images are used to align the low-intensity focused ultrasound (LIFU) and transcranial magnetic stimulation (TMS) devices to temporarily change brain activity. Electromyography (EMG) will be used to record muscle contractions of the hand.

Conditions

• Development of LIFU for Clinical Purposes

Interventions

Type	Name	Description
DEVICE	Low-Intensity Focused Ultrasound	LIFU application using various durations, responses of neuromodulation recorded using TMS and EMG.

Timeline

• Start date: 2022-08-26
• Primary completion: 2026-06-01
• Completion: 2026-06-01
• First posted: 2021-12-07
• Last updated: 2025-07-04

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated device study