NCT05146713

Effect of Propolis Nanoparticles on Postoperative Pain and Bacterial Reduction in Mandibular Premolars

Effect Of Propolis Nanoparticles Versus Sodium Hypochlorite As Root Canal Irrigant On Postoperative Pain And Bacterial Reduction In Mandibular Premolars With Necrotic Pulps (A Randomized Clinical Trial)

• Status: Unknown
• Phase: Phase 2 / Phase 3
• Study type: Interventional
• Enrollment: 44 (estimated)
• Sponsor: Cairo University · Academic / Other
• Sex: All
• Age: 20 Years – 55 Years
• Healthy volunteers: Not accepted

Summary

The aim of this study is to clinically compare the intensity of post-operative pain and the amount of bacterial reduction after using 20mg/ml propolis nanoparticles extract solution during chemo-mechanical preparation, versus 2.5% NaOCl, in asymptomatic necrotic mandibular premolars treated in a single visit.

Conditions

• Necrotic Pulp

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Propolis nanoparticles extract solution	20 mg/ml propolis nanoparticles in the form of solution prepared from honeybee from various plants.
DRUG	sodium hypochlorite	2.5% sodium hypochlorite (household bleaching agent)

Timeline

• Start date: 2022-01-01
• Primary completion: 2022-11-01
• Completion: 2022-12-01
• First posted: 2021-12-07
• Last updated: 2021-12-07