NCT05145426

Investigation of Low-intensity Focused Ultrasound for Human Pain Management

• Status: Enrolling By Invitation
• Phase: N/A
• Study type: Interventional
• Enrollment: 80 (estimated)
• Sponsor: Virginia Polytechnic Institute and State University · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

This project examines the effects of noninvasive brain stimulation on pain. The investigators believe this study will help to better understand possible treatments for chronic pain patients. Participants undergo structural imaging, a functional Magnetic Resonance Image (fMRI) and computed tomography (CT). These images are used to align the low-intensity focused ultrasound (LIFU) device which uses sound waves to temporarily change brain activity. Pain testing is done using a small device that will increase/decrease the temperature of the skin. Brain signals are collected using electroencephalography (EEG). Heart rate, blood pressure, and skin moisture will be monitored as well.

Conditions

• Chronic Pain

Interventions

Type	Name	Description
DEVICE	Low Intensity Focused Ultrasound	Application of LIFU

Timeline

• Start date: 2022-02-04
• Primary completion: 2027-01-01
• Completion: 2027-12-01
• First posted: 2021-12-06
• Last updated: 2026-03-31

Locations

1 site across 1 country: United States