NCT05144672

Irisin And Diabetic Nephropathy

Irisin Level in Patients With Diabetic Nephropathy

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 90 (estimated)
• Sponsor: Assiut University · Academic / Other
• Sex: All
• Age: 40 Years
• Healthy volunteers: Not accepted

Summary

Diabetes mellitus (DM) is a complex, multifactorial, chronic metabolic and endocrine disorder. It has become a threat to global health. It has two types. It is estimated that the number of people with type II will reach 700 million by 2045.

Detailed description

It is associated with acute and chronic complications, acute complications include hypoglycemia, diabetic ketoacidosis, hyperglycemic hyperosmolar state, and hyperglycemic diabetic coma. Chronic complications are further divided into microvascular and macrovascular complications. Chronic microvascular complications are neuropathy, retinopathy, and nephropathy. The later one firstly diagnosed by microalbuminuria. whereas chronic macrovascular complications are coronary artery disease (CAD), peripheral artery disease (PAD), and cerebrovascular disease. The conventional medications in diabetes treatment, oral and insulin, are focusing on insulin secretion and insulin sensitisation. Oral antidiabetics include, Biguanides, Sulfonylureas, Thiazolidinediones, DPP4 inhibitors, GLP-1 analogue, and SGLT2 inhibitors. Irisin, a myokin and adipokine secreted by muscles and subcutaneous fat, is an interesting peptide performing significant functions in human health. Irisin has been linked to human obesity and insulin resistance status. Irisin is involved in regulating the mitochondrial function of muscle cells, so increases energy consumption of the body, promotes metabolism and reduces body weight so improves insulin sensetivity. In our study we aim to clarify the effect of antidiabetics on serum irisin in patients with typeII DM who developed diabetic nephropathy.

Conditions

• Irisin

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Laboratory tests	Fasting blood glucose (FBG), postprandial blood glucose, total cholesterol (CHO), triglycerides (TG), high-density lipoprotein cholesterol and low-density lipoprotein cholesterol (LDL-C), urea, creatinine, and uric acid by point colorimetric assay. Serum irisin.
OTHER	Anthropometric measurements	Height, weight, waist circumference, and hip circumference were taken as a way of assessing the nutritional status and BMI
PROCEDURE	Electrocardiogram and Fundus examination	Fundus examination by direct ophthalmoscope
OTHER	Estimated glomerular filtration rate (eGFR)	Estimated glomerular filtration rate (eGFR) was calculated by EPI equation.
OTHER	Brachial index	The ankle-brachial index test compares the blood pressure measured at your ankle with the blood pressure measured at your arm
DIAGNOSTIC_TEST	Laboratory tests	Glycosylated haemoglobin. ACR,urinary albumin (mg) and creatinine (g).
RADIATION	Abdominal ultrasound.	It will be performed for patients only.

Timeline

• Start date: 2022-01-01
• Primary completion: 2023-04-30
• Completion: 2023-06-30
• First posted: 2021-12-03
• Last updated: 2021-12-03