NCT05144451

Transcranial Doppler During Liver Transplantation

Transcranial Doppler and Neurological Complications After Liver Transplantation

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 100 (estimated)
• Sponsor: Mansoura University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This is a prospective study that would investigate the transcranial doppler (TCD) changes during the living donor liver transplantation and the association between the TCD changes and the post-transplant neurological complications.

Detailed description

Objectives: Participants \& Setting: Intervention \& Measurements: Sample size:

Conditions

• Liver Transplantation
• Ultrasonography, Doppler, Transcranial
• Complication, Postoperative
• Neurologic Deficits

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Transcranial Doppler	Transcranial Doppler-derived parameters; pulsatility index (PI), resistance index (RI), mean flow velocity (Vmean) will be recorded before induction of anesthesia (T1). After induction, TCD parameters, Hemodynamic variables including heart rate (HR), invasive mean arterial blood pressure (MAP), and central venous pressure (CVP) together with Arterial blood gases (ABG analysis with values of PH, PCO2, PO2, blood oxygen saturation SO2 and bicarbonate HCO3), end-tidal carbon dioxide (ETCO2) and body temperature will be recorded too. Just before skin incision (T2), at the end of anhepatic phase 5 minutes before reperfusion (T3), 5 minutes after reperfusion (T4) and at the end of surgery (T5). Postoperatively at ICU, TCD parameters, Hemodynamic variables, and ABG will be obtained 24 hours postoperative (T6) and at discharge from ICU (T7).

Timeline

• Start date: 2021-11-28
• Primary completion: 2023-11-28
• Completion: 2024-04-28
• First posted: 2021-12-03
• Last updated: 2022-04-14

Locations

1 site across 1 country: Egypt