NCT05141383

Comparative Study of Diagnostic and Prognosis Biomarkers of Prostate Cancer in Liquid Biopsy (HOPE)

Comparative Study of Diagnostic and Prognosis Biomarkers of Prostate Cancer in Liquid Biopsy

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 80 (actual)
• Sponsor: Institut Curie · Academic / Other
• Sex: Male
• Age: 50 Years – 70 Years
• Healthy volunteers: Accepted

Summary

Constitution of a biological collection within the framework of the establishment of a diagnostic, prognostic and active surveillance test for prostate cancer from long non-coding RNA biomarkers, in 3 cohorts of patients, with cancer of the prostate, with suspected cancer without biopsy confirmation or with prostatic hyperplasia and healthy donors. This biological collection will also be used as a support for further researches on the identification of biomarkers and genetic markers to improve the prognosis and diagnostic management of patients with prostate pathologies.

Detailed description

Multicenter, RIPH 2 study, evaluating on 3 patient cohorts the feasibility of setting up a diagnostic test, prognosis and active surveillance of prostate cancer using long non-coding RNA biomarkers. For patients agreeing to participate in the study and having signed a consent form, during their routine care consultation in the urology department, will have a blood sample and a urine sample after prostate massage as part of the study, and if necessary, a tissue sample as part of the treatment. Patients with prostate cancer will be followed as part of their care at least annually, and their follow-up data will be collected as part of the study, without additional sampling. A blood sample and a urine sample after prostate massage will be carried out during a single consultation at the CIC Henri Mondor for

Conditions

• Prostate Cancer
• Healthy Donors

Interventions

Type	Name	Description
OTHER	Urine sampling	A blood sample and a urine sample after prostate massage will be carried out at baseline

Timeline

• Start date: 2022-05-04
• Primary completion: 2024-09-03
• Completion: 2024-09-03
• First posted: 2021-12-02
• Last updated: 2025-09-08

Locations

1 site across 1 country: France