NCT05137743

Pilot Test of Apnea and Insomnia Relief for Veterans With Gulf War Illness

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 80 (estimated)
• Sponsor: University of California, San Francisco · Academic / Other
• Sex: All
• Age: 48 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to determine whether a behavioral sleep treatment improves sleep and other Gulf War Illness (GWI) symptoms in Gulf War Veterans with GWI.

Detailed description

This study is a randomized controlled trial of a behavioral sleep treatment to improve sleep and other symptoms of Gulf War Illness (GWI) in Gulf War (GW) Veterans with GWI, sleep apnea, and insomnia. The treatment is delivered via telehealth (video to home) or telephone. The primary outcome for this study is the severity of Gulf War Illness symptom severity. Other outcomes include sleep-related functioning, insomnia symptom severity, and positive airway pressure (PAP) adherence.

Conditions

• Gulf War Illness

Interventions

Type	Name	Description
BEHAVIORAL	Apnea and Insomnia Relief (AIR)	This treatment will be offered over six sessions. All appointments will be conducted via telehealth and will last 60 minutes. The main components of the AIR protocol are (a) psychoeducation, (b) motivational interviewing, (c) PAP adherence strategies, and (d) cognitive behavioral therapy for insomnia.
BEHAVIORAL	Sleep Education (SE)	This treatment will be offered over six sessions. All appointments will be conducted via telehealth and will last 60 minutes. Topics covered include the sleep cycle, sleep across the lifespan, sleep and the mind, evening activities and the sleep environment, and daytime activities and sleep.

Timeline

• Start date: 2022-02-15
• Primary completion: 2026-03-31
• Completion: 2026-07-31
• First posted: 2021-11-30
• Last updated: 2026-02-09

Locations

1 site across 1 country: United States