NCT05136378

Selenious Yeast in CLL Patients w/o Indication of Chemotherapy

Administration of Selenious Yeast Tablets in Chronic Lymphocytic Leukemia Patients Without Indication of Chemotherapy: A Multicenter Study

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (estimated)
• Sponsor: Shanghai Zhongshan Hospital · Academic / Other
• Sex: All
• Age: 17 Years – 99 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to evaluate the safety and effectiveness of Selenious Yeast Tablets in Chronic Lymphocytic Leukemia Patients without Indication of Chemotherapy

Detailed description

A large portion of CLL patients has no indications of chemotherapy when diagnosed. In patients with CLL, the mean serum selenium levels are lower than normal. There is a correlation between the selenium level and the clinical stage. We discovered that sodium selenite inhibited the expression of CXCL-1 and restored the defective necroptotic pathway of CLL cells together with TNF-α and z-VAD in vitro. The purpose of this study is to evaluate the safety and effectiveness of Selenious Yeast Tablets in preventing CLL patients without indication of chemotherapy from disease development.

Conditions

• Chronic Lymphocytic Leukemia Stage A(0)
• Chronic Lymphocytic Leukemia Stage A(I)
• Chronic Lymphocytic Leukemia Stage A(II)
• Chronic Lymphocytic Leukaemia Stage B(I)

Interventions

Type	Name	Description
DRUG	Low Dose Selenious Yeast Tablets	Low dose of Selenious Yeast Tablets
DRUG	High Dose Selenious Yeast Tablets	High Dose Selenious Yeast Tablets

Timeline

• Start date: 2021-11-01
• Primary completion: 2023-12-31
• Completion: 2025-12-31
• First posted: 2021-11-29
• Last updated: 2021-11-29

Locations

1 site across 1 country: China