NCT05132309

Intestinal Microbiota Composition in Patients With Chronic Pancreatitis and Pancreatic Exocrine Insufficiency

Study of Influence of Chronic Pancreatitis Severity Degree With Possible Complication of Pancreatic External Secretory Insufficiency on Intestinal Microbiota Composition Patterns

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 96 (actual)
• Sponsor: Federal Research and Clinical Center of Physical-Chemical Medicine · Academic / Other
• Sex: All
• Age: 23 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

Assessment of qualitative and quantitative composition of the intestinal microbiota in patients with CP; in patients with CP and PEI complication of mild to severe degree; patients with CP and PEI who underwent surgical intervention on the pancreas. Intergroup comparison of the microbial compositional characteristics and their analysis. Correction of enzyme replacement therapy in selected groups of patients with regard to the identified microbial characteristics. Assessment of the intestinal microbiota composition in dynamics after 6 (+1) months on the background of allocated therapy

Conditions

• Chronic Pancreatitis
• Pancreatic Exocrine Insufficiency

Interventions

Type	Name	Description
COMBINATION_PRODUCT	enzyme replacement therapy	Correction of the previously prescribed dose of enzyme replacement therapy (ERT)/first time selection of ERT according to the severity of pancreatic exocrine insufficiency

Timeline

• Start date: 2020-11-01
• Primary completion: 2021-07-01
• Completion: 2021-07-01
• First posted: 2021-11-24
• Last updated: 2021-11-24

Locations

2 sites across 1 country: Russia