NCT05132192

Living Donor Liver Transplantation to Patients With Portal Vein Thrombosis

Outcomes of Surgical Strategies for Living Donor Liver Transplantation to Patients With Portal Vein Thrombosis

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 335 (actual)
• Sponsor: Elvan Onur Kirimker · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Data of demographic, clinical, laboratory and imaging studies of living donor liver transplantation (LDLT) recipients from two transplant centers were collected. Survival and morbidity rates between patients with and without portal vein thrombosis (PVT) were compared. Risk factors of mortality in the setting of PVT were identified. Intraoperative portal flow measurements were compared before and after portal flow restoration.

Detailed description

LDLTs performed in two experienced centers (Ankara University Ibn-i Sina Hospital and Ankara Güven Hospital) between January 2013 and February 2020 were evaluated and included in the cohort study. Deceased donor liver transplants and pediatric transplants (deceased or living) were excluded from the study. Data relating to this study including patient history, preoperative laboratory and imaging test results, reports of surgical procedures or interventions, intraoperative anesthesia records, post-operative laboratory trends, and postoperative complications were extracted from the computer-based data management system and prospectively maintained in transplant databases in both centers. Recipients of LDLT were divided in two groups according to the presence or absence of PVT. Portal flow measurements were recorded with VeriQ (Medistim ASA, Oslo, Norway) Doppler flowmeter device in one of the centers later in the study period. The follow-up and recordings of the patients were maintained in the outpatient clinics of the two centers. The most serious complication experienced by each patient was recorded according to the Clavien-Dindo classification Primary outcome of the current study was the survival rates of patients with and without PVT Secondary outcomes of the study included morbidity in patients with and without PVT after LDLT, risk factors of mortality after LDLT to patients with PVT and comparison of intraoperative portal flow measurements between patients with and without PVT

Conditions

• Portal Vein Thrombosis
• Liver Transplant; Complications

Interventions

Type	Name	Description
PROCEDURE	living donor liver transplantation	Living donor liver transplantation
PROCEDURE	Thrombectomy or interposition graft	Portal flow restoration due to PVT in any manner

Timeline

• Start date: 2013-01-01
• Primary completion: 2020-07-30
• Completion: 2020-10-30
• First posted: 2021-11-24
• Last updated: 2021-11-24