NCT05131867

Management of Cerebral Vascular Spasm in Posttraumatic Subarachnoid Hemorrhage Using Combination Therapy

Management of Cerebral Vascular Spasm in Posttraumatic Subarachnoid Hemorrhage Using Combination Therapy of Oral Nimodipine and Intravenous Milrinone: Randomized Clinical Trial

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 30 (actual)
• Sponsor: Zagazig University · Other Government
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

To evaluate the efficacy and safety of oral Nimodipine and IV milrinone combination therapy for management of cerebral spasm after aneurysmal subarachnoid hemorrhage.

Detailed description

after being informed about the study and potential risks. All patients giving written consent will be randomized by double-blind manner into 2groups each one containing 15 patients. Group 1(n =15 ):the patients will receive nimodipine (60 mg/4 hours) orally or via nasogastric tube In group 2(n =15 ): the patients will receive Oral Nimodipine (60 mg/4) will be given orally or in the gastric tube also from the first day of admission, then after the diagnosis of vasospasm is confirmed, start milrinone.

Conditions

• Oral Nimodipine
• Milrinone
• Vascular Spasm After Traumatic Subarachnoidhaemorrhage

Interventions

Type	Name	Description
DRUG	nimodipine	(60 mg/4 hours) orally or via nasogastric tube
DRUG	Oral Nimodipine and milrinone	Oral Nimodipine then after the diagnosis of vasospasm is confirmed, start milrinone bolus

Timeline

• Start date: 2021-11-24
• Primary completion: 2022-05-23
• Completion: 2022-05-24
• First posted: 2021-11-23
• Last updated: 2022-05-25

Locations

2 sites across 1 country: Egypt