Trials / Completed
CompletedNCT05131555
Influence of Endurance Exercise and Histamine Receptors on the Gene Expression in Skeletal Muscle
Influence of Endurance Training and Histamine Receptor Antagonists on the Transcriptome Response in Human Muscle
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 14 (actual)
- Sponsor
- University Ghent · Academic / Other
- Sex
- All
- Age
- 18 Years – 45 Years
- Healthy volunteers
- Accepted
Summary
Blocking histamine H1/H2 receptors blunts chronic endurance training adaptations. The current study addresses a twofold research question: "What is the influence of endurance training (1) and histamine H1 and H2 signaling (2) on the gene expression in human skeletal muscle." Results from this study will yield more insights into the molecular mechanisms of adaptations to exercise training.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Placebo: Placebo + exercise training. | Oral placebo Exercise training: Interval-based cycling exercise |
| DRUG | H1 blockade: H1 receptor antagonist + exercise training | H1 blockade: oral blockade Exercise training: Interval-based cycling exercise |
| DRUG | H2 Blockade: H2 receptor antagonist + exercise training | H2 blockade: oral blockade Exercise training: Interval-based cycling exercise |
Timeline
- Start date
- 2021-08-16
- Primary completion
- 2021-12-06
- Completion
- 2021-12-31
- First posted
- 2021-11-23
- Last updated
- 2024-04-12
Locations
1 site across 1 country: Belgium
Source: ClinicalTrials.gov record NCT05131555. Inclusion in this directory is not an endorsement.