NCT05126667

Analysis of Breast-Conserving Surgery Plus Whole-Breast Irradiation Versus Mastectomy

A Propensity Score-Matched Analysis of Breast-Conserving Surgery Plus Whole-Breast Irradiation Versus Mastectomy in Breast Cancer

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 9,710 (actual)
• Sponsor: European Institute of Oncology · Academic / Other
• Sex: Female
• Age: —
• Healthy volunteers: Not accepted

Summary

This is a retrospective propensity score-matched analysis of a large institutional cohort of patients in order to compare long-term outcomes and clinicopathologic characteristics between patients treated with breast conserving surgery or mastectomy for breast cancer.

Detailed description

The aim of the study is to compare long-term outcomes and clinicopathologic characteristics between patients treated with breast conserving surgery + whole breast irradiation or mastectomy for breast cancer. Recent observations regarding long-term outcomes among patients with early-stage breast cancer who underwent breast-conserving surgery plus whole-breast irradiation or mastectomy are from a small number of registry-based studies. Therefore, these findings may overestimate differences in survival between the two groups, compared with randomized controlled trials conducted in the 1980s. This study performed a propensity score-matched analysis in a cohort of 9710 patients aged \<70 years who underwent breast conserving surgery + whole breast irradiation or mastectomy without external radiotherapy for a first primary breast cancer (pT1-2, N0-3a) at the European Institute of Oncology between 2000 and 2008. Patients were matched by propensity score.

Conditions

• Breast Cancer

Interventions

Type	Name	Description
PROCEDURE	Breast-conserving surgery	Breast conserving surgery plus whole breast irradiation
PROCEDURE	Mastectomy	Breast mastectomy

Timeline

• Start date: 2000-01-01
• Primary completion: 2021-11-01
• Completion: 2021-11-01
• First posted: 2021-11-19
• Last updated: 2021-11-19