NCT05126264

Efficacy of Chronoterapy in Oral Surgery

Efficacy of the Dosage of a Non-steroidal Anti-inflammatory (Ibuprofen) on Inflammation and Postoperative Pain After Lower Third Molar Surgery.

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 10 (actual)
• Sponsor: Universidad Complutense de Madrid · Academic / Other
• Sex: All
• Age: 18 Years – 35 Years
• Healthy volunteers: Accepted

Summary

Lower third molar extraction is one of the most common treatments in oral surgery practice. It is a treatment with inherent complications such as postoperative pain, swelling or trismus. In order to minimize disconfort after extraction, analgesic and anti-inflammatory medication is prescribed. Recently, it is seen that circadian rhythm may play an important role on drugs metabolism, modulating its effect depending on the moment of administration. The aim of the study is to analyze if dosage modification of a Non Steroideal Anti-Inflammatory (ibuprofen) affects on postoperative pain, swelling and open mouth limitation comparing to the normal dosage.

Detailed description

A randomized crossover split-mouth clinical trial will be performed. After third molar extractions, patients will be prescribed ramdomly in one side wit the normal medication dosage while the contralateral side will be prescribed a modified dosage. Moreover, a blood sample will be obtained to analize the inflammatory profile.

Conditions

• Tooth, Impacted
• Trismus
• Pain
• Inflammatory Response

Interventions

Type	Name	Description
DRUG	Ibuprofen 400 mg	morning and afternoon
DRUG	Ibuprofen 400 mg	morning, afternoon and night

Timeline

• Start date: 2021-12-10
• Primary completion: 2021-12-10
• Completion: 2022-02-02
• First posted: 2021-11-18
• Last updated: 2022-02-03

Locations

1 site across 1 country: Spain