NCT05124912

REMASTer: REcurrent Brain Metastases After SRS Trial

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 261 (estimated)
• Sponsor: Monteris Medical · Industry
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Randomized, post-market multi-center study investigating the efficacy of two sets of treatment algorithms in brain metastases (BM) patients at the time of first intervention for radiographic progression after stereotactic radiosurgery (SRS), with or without surgery.

Conditions

• Brain Metastases
• Radiation Necrosis
• Recurrent Tumor
• Recurrent Metastases

Interventions

Type	Name	Description
PROCEDURE	Radiation Therapy	Post-op hypofractionated therapy or no radiation therapy
DRUG	Steroid Therapy	Best medical management with steroid therapy
PROCEDURE	Laser Interstitial Thermal Therapy	Minimally invasive technique to necrotize intracranial lesions using the NeuroBlate® System (NBS)

Timeline

• Start date: 2022-05-10
• Primary completion: 2026-12-01
• Completion: 2028-10-01
• First posted: 2021-11-18
• Last updated: 2026-02-20

Locations

9 sites across 1 country: United States

Regulatory

• FDA-regulated device study