NCT05124132

Resilience and Brain Health of Older Adults (MEDEX-2)

• Status: Enrolling By Invitation
• Phase: N/A
• Study type: Interventional
• Enrollment: 468 (estimated)
• Sponsor: Washington University School of Medicine · Academic / Other
• Sex: All
• Age: 65 Years
• Healthy volunteers: Not accepted

Summary

This project capitalizes on a natural experiment imposed by the COVID-19 pandemic in conjunction with an extensive set of cognitive, emotional, biological, and neuroimaging variables already collected at multiple time points in older adults participating in a clinical trial of exercise and mindfulness. This project will elucidate the effects of stress on cognitive function and emotional health in later life, including biological measures of Alzheimer Disease risk, stress, and aging, with the ultimate goal of discovering how to mitigate these effects, among older adults who have made and maintained a lifestyle change.

Conditions

• Age-related Cognitive Decline

Interventions

Type	Name	Description
BEHAVIORAL	Mindfulness-Based Stress Reduction	Mindfulness-Based Stress Reduction
BEHAVIORAL	Exercise	Exercise
BEHAVIORAL	Mindfulness-Based Stress Reduction + Exercise	Mindfulness-Based Stress Reduction + Exercise
BEHAVIORAL	Health Education	Health Education

Timeline

• Start date: 2019-04-16
• Primary completion: 2026-08-31
• Completion: 2026-08-31
• First posted: 2021-11-17
• Last updated: 2025-06-18

Locations

1 site across 1 country: United States