NCT05122299

the Effect of coenzymeq10/Collagen Hydrogel on Bone Regeneration in Extraction Socket

The Effect of coenzymeq10/Collagen Hydrogel on Bone Regeneration in Extraction Socket Prior to Implant Placement in Type ii Diabetic Patients (A Randomized Controlled Clinical Trial)

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 18 (actual)
• Sponsor: Hams Hamed Abdelrahman · Academic / Other
• Sex: All
• Age: 30 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

To investigate the effect of CoQ10 in soft tissue healing and bone regeneration after extraction in diabetic patients seeking dental implants. Methods: This study will be a randomized controlled clinical trial, 18 patients will be divided equally into three groups. In-vitro studies will be performed to investigate the release of CoQ10 from collagen, swelling ratio, and evaluation of gelation behavior. The patients will undergo tooth extraction and filling of the socket with either collagen or CoQ10/collagen. Empty sockets will serve as a negative control. The bone regeneration of the socket will be determined by radiography, histology, histomorphometry, and polymerase chain reaction (PCR) for bone markers.

Conditions

• Dental Implants

Interventions

Type	Name	Description
PROCEDURE	Negative control group	No intervention after extraction then delayed implant insertion at the site of extraction after three months
PROCEDURE	Postive control	Application of collagen only in the socket after extraction then delayed implant insertion at the site of extraction after three months.
PROCEDURE	Study group	Application of acombination of CoQ10 and collagen hydrogel in the socket after extraction then delayed implant insertion at the site of extraction after three months.

Timeline

• Start date: 2021-03-28
• Primary completion: 2021-09-01
• Completion: 2021-09-01
• First posted: 2021-11-16
• Last updated: 2021-11-16

Locations

1 site across 1 country: Egypt